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Updated: Jun 18, 2026
12:04
The bm12 Inducible Model of Systemic Lupus Erythematosus (SLE) in C57BL/6 Mice
Published on: November 1, 2015
Lupus vulgaris occurring in a locus minoris resistentiae
Richard Long1, Anita Beatch, Mao-Cheng Lee
1Departments of Medicine and Dermatology, University of Alberta, Edmonton, AB, Canada. richard.long@ualberta.ca
Journal of Cutaneous Medicine and Surgery
|November 19, 2009
Summary
Lupus vulgaris, a skin tuberculosis form, can develop at sites of reduced resistance, often triggered by local trauma. Factors like temperature and corticosteroid use may influence Mycobacterium tuberculosis growth in these specific areas.
Area of Science:
- Dermatology
- Infectious Diseases
- Microbiology
Background:
- Lupus vulgaris, a form of cutaneous tuberculosis, presents diagnostic challenges, particularly in cases without disseminated disease or with solitary lesions.
- Understanding the pathogenesis is crucial for effective diagnosis and treatment strategies.
Observation:
- A case of lupus vulgaris is presented occurring at a locus minoris resistentiae (a site of reduced resistance).
- Unique clinical and laboratory findings were utilized to elucidate the lesion's development and treatment response.
Findings:
- The study suggests lupus vulgaris can manifest in areas of reduced resistance.
- Local trauma, elevated temperature, topical corticosteroids, and microbial virulence may promote Mycobacterium tuberculosis proliferation at a locus minoris resistentiae, potentially following a silent bacillemia.
Implications:
- This case highlights the role of local factors in the pathogenesis of cutaneous tuberculosis.
- Recognizing "locus minoris resistentiae" as a potential site for lupus vulgaris is important for clinical suspicion.
- Further research into the interplay of local conditions and M. tuberculosis is warranted.
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