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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...

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Related Experiment Video

Updated: Jun 18, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Mouse models for cancer stem cell research.

Le Cheng1, Anirudh V Ramesh, Andrea Flesken-Nikitin

  • 1Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853, USA.

Toxicologic Pathology
|November 19, 2009
PubMed
Summary
This summary is machine-generated.

Cancer stem cells drive tumor growth and are a therapeutic target. Immunocompetent mouse models are crucial for studying cancer stem cells and developing effective cancer therapies.

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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
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Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Related Experiment Videos

Last Updated: Jun 18, 2026

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples
07:03

Isolation and Functional Assessment of Human Breast Cancer Stem Cells from Cell and Tissue Samples

Published on: October 2, 2020

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging
09:36

Evaluation of Cancer Stem Cell Migration Using Compartmentalizing Microfluidic Devices and Live Cell Imaging

Published on: December 23, 2011

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Research

Background:

  • The cancer stem cell (CSC) concept posits that tumors are sustained by a small population of self-renewing CSCs.
  • CSCs can generate phenotypically diverse cells with lower tumorigenic potential.
  • CSCs are an attractive target for novel cancer therapies.

Purpose of the Study:

  • To evaluate the utility of genetically defined immunocompetent autochthonous mouse models for studying the cancer stem cell concept in human cancers.
  • To understand the role of normal stem cell regulatory mechanisms in carcinogenesis.
  • To review existing mouse models and outline future challenges in CSC research.

Main Methods:

  • Review of existing literature on cancer stem cell research and mouse models.
  • Discussion of the advantages and disadvantages of various immunocompetent autochthonous mouse models.
  • Analysis of the implications of using immunocompromised versus immunocompetent models.

Main Results:

  • Immunocompromised mouse models present limitations for directly testing CSC concepts in human cancers.
  • Immunocompetent autochthonous mouse models offer a valuable platform for CSC research.
  • These models facilitate understanding the link between normal stem cell regulation and cancer development.

Conclusions:

  • Genetically defined immunocompetent autochthonous mouse models are essential for advancing cancer stem cell research.
  • These models enable a more accurate assessment of therapeutic strategies targeting cancer stem cells.
  • Future research should focus on leveraging these models to overcome current challenges in the field.