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Updated: Feb 6, 2026

Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems
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Future developments of nonhormonal systemic therapy for prostatic carcinoma

J A Warner1, W D Heston

  • 1Memorial Sloan-Kettering Cancer Center, New York, New York.

The Urologic Clinics of North America
|February 1, 1991
PubMed

Insights

Prostate cancer is a common male cancer. Despite advances, many men develop metastatic disease and recurrences resistant to current treatments, highlighting the need for new therapeutic targets.

Area of Science:

  • Oncology
  • Urology
  • Molecular Biology

Background:

  • Prostate cancer is the most frequent cancer diagnosed in men globally.
  • Increasing public awareness and screening methods have not fully mitigated the challenge of late-stage diagnosis.
  • Hormonal therapies are initial treatments, but most patients eventually experience tumor recurrence and resistance.

Purpose of the Study:

  • To review the current landscape of prostate cancer treatment and outcomes.
  • To identify unmet needs in managing advanced and recurrent prostate cancer.
  • To explore emerging cellular and molecular targets for novel therapeutic strategies.

Main Methods:

  • Literature review of recent studies on prostate cancer progression and treatment.
  • Analysis of clinical data regarding patient response to hormonal therapy and subsequent resistance.
  • Examination of molecular pathways implicated in castration-resistant prostate cancer.

Main Results:

  • A significant percentage of men are diagnosed with metastatic prostate cancer.
  • Hormone-refractory recurrence is a common and challenging clinical scenario.
  • Current therapies show limited efficacy against advanced, unresponsive tumors.

Conclusions:

  • There is a critical need for innovative treatments for recurrent and metastatic prostate cancer.
  • Understanding the molecular underpinnings of treatment resistance is key.
  • Further research into novel cellular and molecular targets holds promise for future interventions.

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