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Related Experiment Video

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Development of a Benchtop Model for Evaluating the Compatibility of Wound Dressing Materials with Negative Pressure Wound Therapy Systems

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Future developments of nonhormonal systemic therapy for prostatic carcinoma.

J A Warner¹, W D Heston

¹Memorial Sloan-Kettering Cancer Center, New York, New York.

The Urologic Clinics of North America

|February 1, 1991

Summary

Prostate cancer is a common male cancer. Despite advances, many men develop metastatic disease and recurrences resistant to current treatments, highlighting the need for new therapeutic targets.

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Last Updated: Feb 6, 2026

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Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia

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Published on: August 28, 2013

Area of Science:

Oncology
Urology
Molecular Biology

Background:

Prostate cancer is the most frequent cancer diagnosed in men globally.
Increasing public awareness and screening methods have not fully mitigated the challenge of late-stage diagnosis.
Hormonal therapies are initial treatments, but most patients eventually experience tumor recurrence and resistance.

Purpose of the Study:

To review the current landscape of prostate cancer treatment and outcomes.
To identify unmet needs in managing advanced and recurrent prostate cancer.
To explore emerging cellular and molecular targets for novel therapeutic strategies.

Main Methods:

Literature review of recent studies on prostate cancer progression and treatment.
Analysis of clinical data regarding patient response to hormonal therapy and subsequent resistance.
Examination of molecular pathways implicated in castration-resistant prostate cancer.

Main Results:

A significant percentage of men are diagnosed with metastatic prostate cancer.
Hormone-refractory recurrence is a common and challenging clinical scenario.
Current therapies show limited efficacy against advanced, unresponsive tumors.

Conclusions:

There is a critical need for innovative treatments for recurrent and metastatic prostate cancer.
Understanding the molecular underpinnings of treatment resistance is key.
Further research into novel cellular and molecular targets holds promise for future interventions.