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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
[The role of micro-ribonucleic acid in disease development]
Budiman Widjaya1, Jakob Benedict Seidelin, Jørgen Olsen
1Gastroenheden, Medicinsk Sektion, Herlev Hospital, DK-2730 Herlev, Denmark. bwidjaya@dadlnet.dk
Abstract:
MicroRNAs (miRNAs) are small non-coding ribonucleic acids (RNAs) consisting of approximately 22 nucleotides which are believed to control posttranscriptional gene expression by targeting messenger RNA (mRNA) either by degradation or silencing. This article focuses on the importance of miRNAs in different diseases. There are observations or even evidence that miRNA is involved in the pathogenesis of diseases such as autoimmune, cancer, cardio-vascular, metabolic and infectious diseases. The manipulation of the expression of one or several specific miRNAs could prove to be a promising treatment option, and may improve diagnostics and therapeutics in future patient care.
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