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Quantitative analysis of lens changes after vitrectomy by fluorophotometry.
Y Ogura1, T Takanashi, H Ishigooka
1Department of Ophthalmology, Kyoto University, Japan.
American Journal of Ophthalmology
|February 15, 1991
Summary
Vitrectomy significantly increases lens autofluorescence, a marker of oxidative stress, particularly in older patients. This suggests intraoperative protein oxidation may contribute to nuclear cataract development after vitrectomy.
Area of Science:
- Ophthalmology
- Biochemistry
Background:
- Vitrectomy is a common surgical procedure.
- Lens changes, such as nuclear cataract, can occur post-vitrectomy.
Purpose of the Study:
- To quantitatively assess lens autofluorescence after vitrectomy.
- To investigate the relationship between vitrectomy and lens autofluorescence.
Main Methods:
- Fluorophotometry was used to measure lens autofluorescence.
- Unilateral vitrectomy patients (n=13, age 12-75) were compared to their contralateral eyes.
- Follow-up exceeded two years.
Main Results:
- Lens autofluorescence was significantly higher in vitrectomized eyes compared to controls (P = .0003).
- Increased autofluorescence correlated significantly with patient age at vitrectomy (P = .0008).
- No correlation was found with follow-up duration or intraoperative air use.
Conclusions:
- Vitrectomy leads to increased lens autofluorescence, indicating oxidative stress.
- Age at the time of vitrectomy is a key factor in this increase.
- Intraoperative lens protein oxidation is a potential cause of post-vitrectomy nuclear cataract.