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Related Concept Videos

Blood Types02:20

Blood Types

Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
The ABO Blood Group01:12

The ABO Blood Group

The ABO blood group system is a critical element of transfusion medicine, essential for determining blood compatibility in transfusions and organ transplants. It is based on specific antigens, or agglutinogens, present on the surface of red blood cells (RBCs) and corresponding antibodies, or agglutinins, in the blood plasma.
Antigens in the ABO Blood Group System
Antigens are substances that can trigger an immune response, leading to the production of antibodies. In the ABO blood group system,...
Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
Blood Typing01:10

Blood Typing

Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target antigens A,...
Rh Blood Group01:19

Rh Blood Group

The Rhesus (Rh) antigen is crucial in determining blood groups and ensuring compatibility during blood transfusions.
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...

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Related Experiment Video

Updated: Jun 18, 2026

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

Consortium for Blood Group Genes (CBGG): 2008 report.

G A Denomme1, C M Westhoff, L Castilho

  • 1Immunohematology Reference Laboratory, Blood Center of Wisconsin, Milwaukee, WI 53201-72178, USA.

Immunohematology
|November 26, 2009
PubMed
Summary

The Consortium for Blood Group Genes offers a global platform for laboratories performing DNA and RNA testing. This organization provides interaction, guidelines, proficiency programs, and education for blood, platelet, and neutrophil antigen prediction.

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Area of Science:

  • Genetics
  • Immunology
  • Molecular Biology

Background:

  • Laboratories require standardized methods for antigen prediction.
  • DNA and RNA testing are crucial for accurate antigen identification.

Purpose of the Study:

  • To establish a global organization for blood group gene research.
  • To provide a platform for interaction, guideline development, and education.
  • To operate a proficiency program for antigen prediction testing.

Main Methods:

  • Worldwide collaboration among laboratories.
  • Development of standardized testing guidelines.
  • Implementation of proficiency testing programs.

Main Results:

  • A functioning global consortium for blood group gene research.
  • Established guidelines for DNA/RNA testing in antigen prediction.
  • Operational proficiency programs for participating laboratories.

Conclusions:

  • The Consortium for Blood Group Genes facilitates advancements in blood, platelet, and neutrophil antigen prediction.
  • Standardized testing and education are vital for laboratory accuracy.
  • Global cooperation enhances the reliability of genetic antigen testing.