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Updated: Jun 18, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Pituitary apoplexy following endoscopic sinus surgery
Georgios Fyrmpas1, J Constantinidis, N Foroglou
1Department of Otolaryngology Head and Neck Surgery, AHEPA Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece. drfirbas@hotmail.com
Objective:
To highlight the possibility of pituitary apoplexy after functional endoscopic sinus surgery for elimination of sinonasal infection, an important preparatory step for safe trans-sphenoidal access to the pituitary fossa.
Case Report:
A 67-year-old man with a known pituitary macroadenoma developed headache, diplopia and reduced vision after endoscopic middle meatal antrostomy and ethmoidectomy for rhinosinusitis with polyps. Magnetic resonance imaging showed pituitary haemorrhage. The patient underwent emergency endoscopic trans-sphenoidal resection of the tumour, with significant symptomatic improvement. Despite mild right eyelid ptosis and persistent diabetes insipidus, the patient resumed normal activities in a few weeks. To our knowledge, this is the first report of pituitary apoplexy after a nasal operation.
Conclusion:
Pituitary apoplexy is a rare and potentially life-threatening event in high risk patients with pituitary adenomas; it may occur spontaneously or after surgical procedures. Early, combined surgical intervention by rhinologists and neurosurgeons is recommended. The endoscopic trans-sphenoidal approach is a safe and effective technique for the acute management of pituitary apoplexy.
Insights
Pituitary apoplexy, a rare complication, can occur after sinus surgery in patients with pituitary adenomas. Prompt endoscopic surgery by specialists can effectively manage this condition.
Area of Science:
- Otolaryngology
- Neurosurgery
- Endocrinology
Background:
- Functional endoscopic sinus surgery (FESS) is often a prerequisite for pituitary fossa access.
- Pituitary adenomas are tumors of the pituitary gland.
- Pituitary apoplexy is a clinical syndrome characterized by sudden onset of severe headache, visual impairment, and ophthalmoplegia.
Observation:
- A 67-year-old male with a pituitary macroadenoma experienced sudden headache, diplopia, and vision loss post-FESS.
- MRI confirmed pituitary hemorrhage (apoplexy).
- The patient underwent emergency endoscopic transsphenoidal surgery for tumor resection.
Findings:
- The patient showed significant symptomatic improvement after surgery.
- Persistent diabetes insipidus and mild ptosis were noted.
- This is the first reported case of pituitary apoplexy following nasal surgery.
Implications:
- Pituitary apoplexy is a rare but serious risk in patients with pituitary adenomas undergoing nasal procedures.
- Multidisciplinary collaboration between rhinologists and neurosurgeons is crucial for management.
- Endoscopic transsphenoidal surgery offers a safe and effective approach for acute pituitary apoplexy management.
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