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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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When depression complicates childbearing: guidelines for screening and treatment during antenatal and postpartum

Maria Muzik1, Sheila M Marcus, Julie E Heringhausen

  • 1Department of Psychiatry, University of Michigan, Rachel Upjohn Building, Ann Arbor, MI 48109, USA. muzik@med.umich.edu

Obstetrics and Gynecology Clinics of North America
|December 1, 2009
PubMed

Prevalence studies show that 1 in 5 women experience an episode of major depressive disorder during their lifetime. The peripartum period is a prime time for symptom exacerbation and relapse of depressive episodes. Health care providers, specifically those in obstetric care, should be aware of: (1) the frequency of depression in pregnant and postpartum women; (2) signs, symptoms, and appropriate screening methods; and (3) the health risks for the mother and growing fetus if depression is undetected or untreated. Because management of depressed peripartum women also includes care of a growing fetus or breastfeeding infant, treatment may be complex and requires input from a multidisciplinary team, including an obstetrician, psychiatrist, and pediatrician, to provide optimal care.

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