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Related Concept Videos

Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...

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Chronic Salmonella Infection Induced Intestinal Fibrosis
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Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Clostridium difficile and inflammatory bowel disease.

Ashwin N Ananthakrishnan1, Mazen Issa, David G Binion

  • 1Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, WI, USA.

The Medical Clinics of North America
|December 1, 2009
PubMed
Summary
This summary is machine-generated.

Clostridium difficile infection is rising in inflammatory bowel disease (IBD) patients, leading to more severe disease. This review covers diagnosis, treatment, and clinical considerations for C. difficile in IBD.

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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
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Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Microbiology

Background:

  • Rising incidence of Clostridium difficile infection (CDI) globally.
  • Increased CDI prevalence and severity observed in inflammatory bowel disease (IBD) patients.
  • IBD patients represent a vulnerable population for severe CDI outcomes.

Purpose of the Study:

  • To review the impact of CDI on IBD.
  • To discuss diagnostic strategies for CDI in IBD.
  • To outline current treatment options and clinical considerations for CDI in IBD patients.

Main Methods:

  • Literature review of studies on CDI in IBD.
  • Synthesis of data on incidence, disease course, diagnosis, and treatment.
  • Analysis of clinical scenarios specific to IBD.

Main Results:

  • CDI is increasingly diagnosed in IBD patients.
  • IBD patients experience a more severe course of CDI compared to the general population.
  • Specific diagnostic and treatment nuances exist for CDI in IBD.

Conclusions:

  • Effective management of CDI in IBD requires recognizing unique clinical challenges.
  • Prompt diagnosis and tailored treatment are crucial for improving outcomes.
  • Further research is needed to optimize CDI care in IBD patients.