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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

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Published on: September 9, 2012

Factor V Leiden and activated protein C resistance

Olivier Segers1, Elisabetta Castoldi

  • 1Department of Biochemistry, Maastricht University, Maastricht, The Netherlands.

Advances in Clinical Chemistry
|December 2, 2009
PubMed
Summary

Activated protein C (APC) resistance, linked to the FV Leiden mutation, is a major risk factor for venous thrombosis. This review covers APC pathway research, resistance mechanisms, and clinical significance.

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