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Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay
13:08

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Published on: September 9, 2012

Factor V Leiden and activated protein C resistance

Olivier Segers1, Elisabetta Castoldi

  • 1Department of Biochemistry, Maastricht University, Maastricht, The Netherlands.

Advances in Clinical Chemistry
|December 2, 2009
PubMed

Insights

Activated protein C (APC) resistance, linked to the FV Leiden mutation, is a major risk factor for venous thrombosis. This review covers APC pathway research, resistance mechanisms, and clinical significance.

Area of Science:

  • Biochemistry
  • Hematology
  • Genetics

Background:

  • Activated protein C (APC) is a key anticoagulant enzyme.
  • APC inactivates coagulation factors Va and VIIIa, regulating thrombin generation.
  • Deficiencies in protein C or S cause severe thrombotic disorders.

Purpose of the Study:

  • To review the protein C pathway and APC resistance.
  • To summarize current knowledge on FV Leiden mutation and its impact.
  • To discuss the clinical significance and ongoing research in APC resistance.

Main Methods:

  • Literature review of studies on APC, protein C pathway, and thrombosis.
  • Analysis of genetic and molecular mechanisms of APC resistance.
  • Evaluation of clinical data linking APC resistance to venous thrombosis.

Main Results:

  • APC resistance is a significant risk factor for venous thrombosis.
  • The FV Arg506Gln mutation (FV Leiden) is the most common cause of APC resistance.
  • Understanding APC resistance has advanced knowledge of coagulation and thrombosis.

Conclusions:

  • APC resistance, particularly FV Leiden, is crucial in thrombosis pathogenesis.
  • Further research continues to elucidate the protein C pathway and its clinical implications.
  • This review provides a comprehensive overview of APC resistance research.

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