Organically modified MCM-type material preparation and its usage in controlled amoxicillin delivery

Area of Science:

• Materials Science
• Nanotechnology
• Drug Delivery

Background:

• Mesoporous silica MCM-41 is a promising material for drug delivery applications.
• Controlled release of antibiotics like amoxicillin is crucial for effective treatment.
• Surface modification of MCM-41 can enhance its physicochemical properties for improved drug loading and release.

Purpose of the Study:

• To modify MCM-41 with organic groups (APTMS, CPTMS) and l-tryptophane for controlled amoxicillin delivery.
• To investigate the effect of surface functionalization on amoxicillin release kinetics.
• To understand the mechanism regulating amoxicillin release from modified MCM-41.

Main Methods:

• Grafting MCM-41 with 3-aminopropyl trimethoxysilane (APTMS) and 3-chloropropyltriethoxysilane (CPTMS).
• Covalent immobilization of l-tryptophane onto the organic-modified MCM-41.
• Characterization using X-ray diffraction (XRD), N2 adsorption-desorption, and FT-IR spectroscopy.
• In vitro amoxicillin release studies.

Main Results:

• Successful grafting of organic groups onto MCM-41 confirmed by characterization.
• Amoxicillin release percentages after 24h: 33.0% (MCM-41), 12.9% (MCM-41-APTMS), 41.0% (MCM-41-CPTMS).
• L-tryptophane immobilization resulted in slower amoxicillin release rates compared to non-immobilized samples.
• Amoxicillin release was primarily governed by diffusion mechanism.

Conclusions:

• Surface modification of MCM-41 with APTMS, CPTMS, and l-tryptophane effectively controls amoxicillin release.
• The functionalized MCM-41 materials offer potential for improved and sustained antibiotic delivery.
• Diffusion is the key mechanism controlling amoxicillin release from these modified silica matrices.