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SCAP is required for timely and proper myelin membrane synthesis

Mark H G Verheijen1, Nutabi Camargo, Valerie Verdier

  • 1Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Neuroscience Campus Amsterdam, VU University, 1081 HV Amsterdam, The Netherlands. mark.verheijen@cncr.vu.nl

Proceedings of the National Academy of Sciences of the United States of America
|December 2, 2009
PubMed
Summary

Sterol regulatory element-binding protein cleavage activation protein (SCAP) is crucial for myelin lipid synthesis in Schwann cells. Its absence causes hypomyelination, but external lipids offer partial rescue, highlighting SCAP

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