Parental knowledge and attitudes toward hypertrophic cardiomyopathy genetic testing

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Sara M Fitzgerald-Butt1, Lindsey Byrne, Cynthia A Gerhardt

  • 1Center for Molecular and Human Genetics, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. sara.fitzgerald-butt@nationwidechildrens.org

Pediatric Cardiology
|December 2, 2009
PubMed

Insights

Parental interest in genetic testing for hypertrophic cardiomyopathy (HCM) is influenced by knowledge and views. Understanding these factors can improve clinical care for children with HCM.

Area of Science:

  • Genetics
  • Cardiology
  • Pediatrics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a prevalent autosomal dominant disorder associated with sudden cardiac death risk.
  • Clinical genetic testing for HCM is underutilized despite its diagnostic and predictive value.

Purpose of the Study:

  • To assess parental interest in genetic testing for hypertrophic cardiomyopathy (HCM) in children.
  • To identify determinants influencing caregivers' decisions regarding genetic testing for HCM.

Main Methods:

  • A questionnaire was developed and administered to 30 adult caregivers of pediatric HCM patients.
  • Logistic regression analysis was used to identify predictors of interest in genetic testing.

Main Results:

  • While 80% of participants knew about genetic testing generally, only 30% were aware of HCM-specific genetic testing.
  • 62% expressed interest in future genetic testing for their child, with 28% considering it within a year.
  • Younger age, higher education, knowledge of carrier testing, positive views on genetics, and awareness of HCM heritability predicted interest.

Conclusions:

  • Caregiver knowledge and perceptions significantly impact the consideration of genetic testing for pediatric HCM.
  • Healthcare providers can use this framework to enhance understanding and encourage appropriate genetic testing, improving clinical management for pediatric HCM patients.

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