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Hypercapnic respiratory failure due to L-tryptophan-induced eosinophilic polymyositis
M Ivey1, M S Eichenhorn, M R Glasberg
1Division of Pulmonary and Critical Care Medicine, Henry Ford Hospital, Detroit 48212.
Chest
|March 1, 1991
Summary
A 24-year-old man developed severe muscle weakness and respiratory failure after consuming L-tryptophan supplements. This case highlights eosinophilic myositis as a potential diagnosis for unexplained muscle weakness and respiratory distress.
Area of Science:
- Neurology
- Toxicology
- Rheumatology
Background:
- Dietary supplements, including L-tryptophan, are widely used for various health purposes.
- Contaminated or excessive intake of supplements can lead to adverse health effects.
- Eosinophilic myositis is a rare inflammatory condition affecting skeletal muscles.
Observation:
- A young man presented with fever, rash, and myalgias, progressing to hypercapnic respiratory failure and severe limb muscle weakness.
- Muscle biopsy confirmed eosinophilic myositis.
- The condition was linked to the ingestion of large quantities of L-tryptophan dietary supplements.
Findings:
- L-tryptophan-induced eosinophilic myositis can cause significant respiratory muscle weakness.
- Prompt diagnosis and treatment with corticosteroids led to complete recovery.
- This case describes a newly recognized disease entity associated with L-tryptophan supplementation.
Implications:
- Clinicians should consider L-tryptophan-induced eosinophilic myositis in patients with unexplained myopathy and respiratory failure.
- Awareness of potential supplement toxicity is crucial for patient safety.
- Further research is needed to understand the pathogenesis and long-term effects of L-tryptophan-induced eosinophilic myositis.