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Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Secondhand tobacco smoke exposure and chronic rhinosinusitis: a population-based case-control study
Douglas D Reh1, Sandra Y Lin, Sandra L Clipp
1Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins Sinus Center, Johns Hopkins Medicine, Baltimore, Maryland 21287, USA. dreh1@jhmi.edu
American Journal of Rhinology & Allergy
|December 5, 2009
Summary
Secondhand tobacco smoke (SHS) exposure, both in childhood and adulthood, significantly increases the risk of developing chronic rhinosinusitis (CRS). SHS-exposed individuals also experience more severe CRS symptoms and increased nasal decongestant use.
Area of Science:
- Environmental Health
- Otolaryngology
- Epidemiology
Background:
- Chronic rhinosinusitis (CRS) significantly impacts quality of life and incurs substantial healthcare costs.
- Environmental factors, including secondhand tobacco smoke (SHS), are implicated in CRS, yet research remains limited.
- This study investigates the association between SHS exposure and CRS risk in adult nonsmokers.
Purpose of the Study:
- To determine if exposure to secondhand tobacco smoke (SHS) is a risk factor for developing chronic rhinosinusitis (CRS) in adults.
- To assess the impact of SHS exposure on the severity of CRS symptoms and quality of life.
- To evaluate the association between SHS exposure and the use of nasal decongestants in CRS patients.
Main Methods:
- A community-based case-control study involving 100 adult CRS cases and 100 matched controls (nonsmokers).
- Participants were interviewed using a validated questionnaire to assess historical and current SHS exposure.
- Disease-specific quality of life and medication use were evaluated.
Main Results:
- SHS exposure (current or childhood) was associated with a 2.33-fold increased risk of CRS (OR, 2.33; 95% CI, 1.02, 5.34).
- CRS cases exposed to SHS reported significantly worse symptoms, including nasal obstruction, discharge, headaches, and cough.
- SHS-exposed CRS cases were more likely to use nasal decongestants compared to unexposed cases (53.9% vs. 34.4%).
Conclusions:
- Childhood and adult exposure to secondhand tobacco smoke (SHS) may be a significant risk factor for chronic rhinosinusitis (CRS).
- SHS exposure is linked to exacerbated and more severe CRS symptoms, including increased nasal congestion and discharge.
- Individuals with CRS exposed to SHS demonstrate a higher utilization of nasal decongestants, indicating a greater symptom burden.
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