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Controlled steroid delivery via bioabsorbable stent: safety and performance in a rabbit model
Peter M M C Li1, Peter F Li, David Downie
1The Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
American Journal of Rhinology & Allergy
|December 5, 2009
Summary
Mometasone furoate-eluting bioabsorbable stents effectively deliver steroids locally to the sinus mucosa in rabbits, maintaining sinus patency with minimal systemic absorption and good tolerance. This demonstrates potential for reducing inflammation after endoscopic sinus surgery.
Area of Science:
- Otolaryngology
- Biomaterials Science
- Pharmacology
Background:
- Suboptimal sinus patency after surgery can result from middle turbinate lateralization, adhesions, and inflammation.
- A novel bioabsorbable drug-eluting stent delivers steroids to sinus mucosa, aiming to maintain patency.
- This study evaluates the in vivo efficacy and tolerance of this stent in a rabbit model.
Purpose of the Study:
- To characterize the in vivo drug delivery efficacy of a mometasone furoate-coated bioabsorbable stent.
- To assess the tolerance of the drug-eluting stent in the sinus mucosa.
- To evaluate the potential of the stent in maintaining sinus patency and reducing inflammation post-surgery.
Main Methods:
- Bioabsorbable stents with mometasone furoate were implanted in rabbit maxillary sinuses.
- Drug concentrations in sinus/nasal mucosa and plasma were measured over time.
- Histopathological analysis assessed mucosal tolerance and tissue reactions.
Main Results:
- Therapeutic local drug concentrations were achieved in a time-dependent manner (175–28,189 ng/g).
- Plasma drug levels remained negligible, near the limit of quantification.
- Histology revealed no significant difference in tissue reaction between drug-eluting and control stents, with mild inflammation observed.
Conclusions:
- Mometasone furoate-coated bioabsorbable stents provide effective local steroid delivery with minimal systemic absorption in rabbits.
- The stents demonstrated good tolerance in the sinus mucosa.
- These corticosteroid-eluting stents show promise for improving outcomes after endoscopic sinus surgery.
