Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Chitosan-coated cyclodextrin-based niosomes enable enhanced nose-to-brain delivery of rivastigmine and asiaticoside for Alzheimer's disease.

International journal of biological macromolecules·2026
Same author

Cyclodextrin-Based Niosomal Delivery of Imatinib against A549 Nonsmall Cell Lung Cancer Cells.

ACS omega·2026
Same author

Development of piperine/HPβCD-loaded PVA-coated iron oxide nanoparticles in in situ gel for enhanced retinal delivery and anti-VEGF activity.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025
Same author

Cyclodextrin-based formulations for pediatric patients: pharmaceutical prospectives and toxicological evaluation.

The Journal of pharmacy and pharmacology·2025
Same author

The Chemical Stability Characterization and Kinetics of Statins in Aqueous Cyclodextrin Ocular Preparations: A Formulation Perspective.

Pharmaceutics·2025
Same author

A comprehensive nomenclature system for cyclodextrins.

Carbohydrate polymers·2025
Same journal

Design and evaluation of a pump-free ultrasonic atomization-driven hollow microneedle array for transdermal drug delivery.

International journal of pharmaceutics·2026
Same journal

Predicting milling performance of pharmaceutical crystals from elastic modulus.

International journal of pharmaceutics·2026
Same journal

Lipid digestion- driven drug fate as a key determinant of SNEDDS performance: Mechanistic basis of absorption and in vitro- in vivo disconnect.

International journal of pharmaceutics·2026
Same journal

Redox-responsive nanomedicine beyond glutathione: harnessing reactive oxygen species and emerging endogenous triggers for precision drug delivery.

International journal of pharmaceutics·2026
Same journal

Preventing tablet defects through vacuum-assisted deaeration of a powder bed.

International journal of pharmaceutics·2026
Same journal

Approaches for enhancing bioavailability of macromolecular drugs.

International journal of pharmaceutics·2026
See all related articles

Related Experiment Video

Updated: Jun 18, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

Self-assembled cyclodextrin aggregates and nanoparticles.

Martin Messner1, Sergey V Kurkov, Phatsawee Jansook

  • 1Faculty of Pharmaceutical Sciences, University of Iceland, Hagi, Hofsvallagata 53, IS-107 Reykjavik, Iceland.

International Journal of Pharmaceutics
|December 8, 2009
PubMed
Summary
This summary is machine-generated.

Cyclodextrins (CDs) self-assemble into nanoparticles, enhancing their ability to solubilize poorly soluble drugs beyond traditional inclusion complexes. This aggregation significantly boosts drug delivery capabilities.

More Related Videos

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

Related Experiment Videos

Last Updated: Jun 18, 2026

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers
11:42

Synthesis of Monodisperse Cylindrical Nanoparticles via Crystallization-driven Self-assembly of Biodegradable Block Copolymers

Published on: June 20, 2019

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control
06:16

Fabrication of Spherical and Worm-shaped Micellar Nanocrystals by Combining Electrospray, Self-assembly, and Solvent-based Structure Control

Published on: February 11, 2018

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives
09:22

Self-assembling Morphologies Obtained from Helical Polycarbodiimide Copolymers and Their Triazole Derivatives

Published on: February 7, 2017

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Physical Chemistry

Background:

  • Cyclodextrins (CDs) are cyclic oligosaccharides commonly used as pharmaceutical excipients.
  • Their structure features a hydrophilic exterior and a lipophilic cavity, enabling drug solubilization via inclusion complex formation.
  • Recent findings suggest non-inclusion complexes and self-assembly also contribute to drug solubilization.

Purpose of the Study:

  • To review the formation of cyclodextrin (CD) aggregates and nanoparticles.
  • To emphasize the physicochemical properties of self-assembled CDs and their complexes.
  • To explore the role of CD aggregation in solubilizing poorly soluble drugs.

Main Methods:

  • Literature review on cyclodextrin self-assembly and complexation.
  • Analysis of physicochemical properties of CD aggregates and nanoparticles.
  • Investigation of the impact of CD concentration and complexation on aggregation.

Main Results:

  • CDs self-assemble into nanosized aggregates in aqueous solutions, with aggregation increasing significantly with concentration.
  • Formation of CD complexes can enhance aggregation, leading to micellar-type structures.
  • These self-assembled structures contribute to the solubilization of poorly soluble compounds, including those not forming inclusion complexes.

Conclusions:

  • CD self-assembly into nanoparticles is a key mechanism for enhancing drug solubilization.
  • Both inclusion and non-inclusion complexes, alongside self-assembled aggregates, play crucial roles in CD-mediated drug delivery.
  • Understanding these aggregation phenomena is vital for optimizing CD-based pharmaceutical formulations.