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Related Experiment Video

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Engineering Platform and Experimental Protocol for Design and Evaluation of a Neurally-controlled Powered Transfemoral Prosthesis

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Phase-based control of the central pattern generator for locomotion.

R Vogelstein¹, Ralph Etienne-Cummings, Avis H Cohen

¹Johns Hopkins University, Department of Electrical and Computer Engineering, Baltimore, MD USA. jvogelst@jhuapl.edu

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|December 8, 2009

Summary

Electrical stimulation of the lamprey spinal cord precisely timed to the central pattern generator (CPG) cycle enables reliable control of locomotion. This phase-dependent stimulation (PDS) can independently adjust movement parameters for potential neuroprosthetics.

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Area of Science:

Neuroscience
Locomotion Control
Spinal Cord Stimulation

Background:

The lamprey central pattern generator (CPG) controls locomotion.
Previous work showed electrical stimulation can alter CPG activity.

Purpose of the Study:

To demonstrate reliable manipulation of lamprey locomotion parameters using phase-dependent responses (PDR).
To explore the potential of PDR for future spinal locomotion neuroprostheses.

Main Methods:

Applying electrical stimuli to the lamprey spinal cord at specific phases of the CPG cycle.
Analyzing phase-dependent responses (PDR) to characterize stimulus effects.

Main Results:

Phase-dependent stimulation (PDS) precisely prescribes stimulation phases for specific locomotor modifications.
Ipsilateral and contralateral burst durations of locomotion can be controlled independently.
Stimulation effects predicted by a single-cycle PDR plot are stable over multiple cycles.

Conclusions:

Phase-dependent stimulation offers a reliable method for controlling individual parameters of lamprey locomotion.
PDS is a promising technique for developing future spinal locomotion neuroprostheses.