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Renal function after tumor enucleation in a solitary kidney
1Department of Internal Medicine, University Hospital Innsbruck, Austria.
Summary
Renal cell carcinoma enucleation in solitary kidneys did not cause lasting kidney damage. Kidney function largely recovered post-surgery, showing no progressive decline in renal function or proteinuria.
Area of Science:
- Nephrology
- Urology
- Oncology
Background:
- Extensive renal mass ablation's long-term effects in humans remain debated.
- Animal models suggest potential for glomerulosclerosis, proteinuria, and hypertension after renal mass reduction.
Purpose of the Study:
- To investigate kidney function following renal cell carcinoma enucleation in patients with a solitary kidney.
- To assess the risk of progressive renal injury, proteinuria, and hypertension after such procedures.
Main Methods:
- Study included six patients undergoing solitary kidney tumor enucleation.
- Pre- and post-operative serum creatinine levels were monitored.
- Blood pressure and proteinuria were assessed during follow-up (10-23 months).
Main Results:
- Serum creatinine transiently increased post-surgery but largely returned to near-preoperative levels.
- No patients exhibited progressive renal function deterioration or proteinuria.
- Two patients experienced a modest increase in blood pressure.
Conclusions:
- Tumor enucleation in a solitary kidney appears safe in the short term.
- The procedure did not lead to significant, lasting renal injury in the remnant kidney.
- Further long-term studies are warranted to confirm these findings.
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