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Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
Published on: March 27, 2018
Technological advances in renal replacement therapy: five years and beyond.
Anjay Rastogi1, Allen R Nissenson
1Department of Medicine, University of California, Los Angeles, CA 90095, USA. arastogi@mednet.ucla.edu
Clinical Journal of the American Society of Nephrology : CJASN
|December 10, 2009
Summary
Novel technologies like nanotechnology and stem cells offer promising new avenues for renal replacement therapy (RRT) to combat chronic kidney disease. These innovations aim to create artificial kidneys that better mimic natural function, improving patient outcomes and addressing organ scarcity.
Area of Science:
- Nephrology
- Biotechnology
- Medical Devices
Background:
- Chronic kidney disease (CKD) is a global epidemic with high morbidity and mortality.
- Current renal replacement therapies (RRT), including dialysis and transplantation, have significant limitations such as high costs, patient burden, and organ scarcity.
Purpose of the Study:
- To explore emerging technologies that could lead to ideal RRT mimicking natural kidney function.
- To assess the potential of nanotechnology, microfluidics, bioreactors, and stem cells in advancing RRT.
Main Methods:
- Review of recent technological advancements in RRT.
- Focus on nanotechnology, microfluidics, kidney cell bioreactors, and miniaturized sorbent systems.
- Exploration of stem cell applications for kidney disease and organ regeneration.
Main Results:
- Emerging technologies show potential for creating artificial kidneys that are transparent to patients and affordable.
- Nanotechnology, microfluidics, and bioreactors are nearing clinical application.
- Stem cells offer significant promise for treating kidney disease and generating tissues/organs.
Conclusions:
- Nephrology is at a pivotal point with the integration of innovative technologies for RRT.
- These novel approaches hold considerable promise for improving the future of kidney disease treatment and patient care.
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