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Updated: Jun 17, 2026

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
Published on: December 7, 2021
Elucidation of multifaceted evolutionary processes of microorganisms by comparative genome-based analysis
Thuy Vu An Nguyen1, Soon Ho Hong, Sang Yup Lee
1School of Chemical Engineering & Bioengineering, University of Ulsan102 Daehakro, Nam-gu, Ulsan 680-749, Korea.
Abstract:
The evolution of living organisms occurs via a combination of highly complicated processes that involve modification of various features such as appearance, metabolism and sensing systems. To understand the evolution of life, it is necessary to understand how each biological feature has been optimized in response to new environmental conditions and interrelated with other features through evolution. To accomplish this, we constructed contents-based trees for two-component system (TCS) and metabolic network to determine how the environmental communication mechanism and the intracellular metabolism have evolved, respectively. We then conducted a comparative analysis of the two trees using ARACNE to evaluate the evolutionary and functional relationship between TCS and metabolism. The results showed that such integrated analysis can give new insight into the study of bacterial evolution.
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