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Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endophthalmitis in eyes presenting with orbital signs: a case-control study
Pukhraj Rishi1, Ekta Rishi, Krishnendu Nandi
1Shri Bhagwan Mahavir Vitreoretinal Services, Sankara Nethralaya, 18 College Road, Chennai 600006, Tamil Nadu, India. docrishi@yahoo.co.in
Retina (Philadelphia, Pa.)
|December 10, 2009
Summary
Orbital signs in endophthalmitis patients indicate a higher risk of poor visual and structural outcomes. Early detection and treatment are crucial for managing this severe ocular infection.
Area of Science:
- Ophthalmology
- Infectious Diseases
Background:
- Endophthalmitis is a severe intraocular infection.
- Orbital signs can indicate advanced disease or complications.
Purpose of the Study:
- To evaluate the clinical characteristics and treatment results of endophthalmitis with orbital signs.
- To determine if orbital signs impact outcomes in endophthalmitis patients.
Main Methods:
- A case-control study compared 24 eyes with endophthalmitis and orbital signs to 40 eyes without orbital signs.
- Orbital signs included motility restriction or specific ultrasonography findings.
- Outcomes were assessed based on structural integrity (inflammation resolution, phthisis bulbi) and visual acuity (improvement to ≥3/60).
Main Results:
- Eyes with orbital signs had significantly poorer visual (P=0.05) and structural (P=0.004) outcomes.
- Only 25% of eyes with orbital signs achieved optimal structural outcome.
- Vision ≥3/60 was achieved in only 16.66% of eyes with orbital signs, compared to 62.5% in controls (P=0.001).
Conclusions:
- Orbital signs are independent risk factors for adverse outcomes in endophthalmitis.
- The presence of orbital signs necessitates aggressive management and portends a guarded prognosis.
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