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Related Experiment Videos

Selenium in pediatric nutrition.

R E Litov1, G F Combs

  • 1Mead Johnson Research Center, Bristol-Myers Squibb Company, Evansville, Indiana 47721-0001.

Pediatrics
|March 1, 1991
PubMed
Summary
This summary is machine-generated.

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Selenium (Se) is vital for antioxidant protection, with deficiency causing diseases like Keshan and Kaschin-Beck. Plasma Se concentration is a key indicator of nutritional status, especially in infants and children.

Area of Science:

  • Nutritional Biochemistry
  • Human Physiology
  • Pediatric Nutrition

Background:

  • Selenium (Se) is an essential trace element crucial for antioxidant defense, primarily through selenoproteins like SeGSHpx.
  • Plasma Se concentration serves as a practical measure of Se nutritional status, with typical ranges for healthy children.
  • Se deficiency, though rare, is recognized in humans, leading to conditions such as Keshan disease (cardiomyopathy) and Kaschin-Beck disease (chondrodystrophy).

Purpose of the Study:

  • To review the role of selenium in human health and nutrition.
  • To discuss the assessment of selenium status, particularly in infants and children.
  • To provide updated recommended daily dietary allowances for selenium.

Main Methods:

  • Literature review of selenium's biochemical functions and deficiency manifestations.

Related Experiment Videos

  • Analysis of plasma Se concentrations as an indicator of nutritional status.
  • Revision of recommended daily dietary allowances for infants and children based on updated data.

    • Main Results:

    • Plasma Se concentration is a reliable indicator of Se intake and status.
    • Severe Se deficiency can lead to specific human diseases.
    • Long-term total parenteral nutrition (TPN) can result in Se deficiency, necessitating supplementation.
    • Updated dietary recommendations for Se intake have been established for various age groups.

    Conclusions:

    • Adequate selenium intake is essential for preventing deficiency diseases and maintaining overall health.
    • Plasma Se concentration is a valuable tool for monitoring nutritional status.
    • Specific populations, including infants and children on long-term TPN, require careful attention to selenium intake and potential supplementation.