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Hypertension and hemostatic/fibrinolytic balance disorders
1Department of Internal Medicine, Istanbul Education and Research Hospital, Istanbul, Turkey.
Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|December 17, 2009
Summary
Hypertension is linked to impaired fibrinolysis, with elevated levels of plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (tPA) observed. These fibrinolytic disturbances may precede cardiovascular events in hypertensive patients.
Area of Science:
- Cardiovascular Medicine
- Hematology
- Hypertension Research
Background:
- Hypertension is a primary risk factor for cardiovascular disease.
- Fibrinolytic balance and endothelial function are crucial in cardiovascular health.
- Investigating the link between hypertension and fibrinolysis is essential for understanding disease progression.
Purpose of the Study:
- To evaluate the impact of hypertension on fibrinolytic balance.
- To measure plasma levels of key fibrinolytic markers and fibrinogen in hypertensive patients.
- To assess the relationship between hypertension and endothelial function indicators.
Main Methods:
- Study included 22 essential hypertensive (EH), 22 white coat hypertensive (WCH), 22 renovascular hypertensive (RH), and 22 normotensive control subjects.
- Plasma levels of plasminogen activator inhibitor-1 (PAI-1), tissue plasminogen activator antigen (tPA), and tPA/PAI-1 complex were measured.
- Enzyme-linked immunosorbent assays (ELISAs) were utilized for plasma level measurements.
Main Results:
- Hypertensive groups (EH, WCH, RH) showed increased plasma levels of PAI-1, tPA, tPA/PAI-1 complex, and fibrinogen compared to controls.
- No significant differences in systolic or diastolic blood pressure were found between EH and RH groups.
- No fibrinolytic parameter was directly associated with blood pressure levels within the hypertensive subjects.
Conclusions:
- Fibrinolytic markers (PAI-1, tPA, tPA/PAI-1 complex) are independently associated with hypertension development.
- Disturbances in fibrinolysis are suggested to precede cardiovascular events.
- Hypertension may be linked to impaired fibrinolytic activity, highlighting potential therapeutic targets.
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