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Related Concept Videos

Drug Discovery: Overview01:26

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Targets for Drug Action: Overview01:26

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Patch Clamp01:18

Patch Clamp

Many fundamental cell functions such as muscle contraction and nerve transmission rely on the electrical signals produced by the movement of positively and negatively charged ions across the cell membrane. One competent method to record current flowing across the whole cell or single ion channel is the patch-clamp technique.
In this method, a glass micropipette containing electrolyte solution is tightly sealed against a small portion of the cell membrane. As a result, a patch of the cell...

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Related Experiment Video

Updated: Jun 17, 2026

A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction
05:28

A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

Recent advances and method development for drug target identification.

Janet N Y Chan1, Corey Nislow, Andrew Emili

  • 1Department of Molecular Genetics, Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada M5S 3E1.

Trends in Pharmacological Sciences
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Identifying drug targets is crucial for understanding drug mechanisms and preventing side effects, especially with polypharmacy. This review explores systematic methods for characterizing bioactive compound targets.

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Protein Target Prediction and Validation of Small Molecule Compound
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Last Updated: Jun 17, 2026

A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction
05:28

A Semi-Quantitative Drug Affinity Responsive Target Stability (DARTS) assay for studying Rapamycin/mTOR interaction

Published on: August 27, 2019

Protein Target Prediction and Validation of Small Molecule Compound
10:21

Protein Target Prediction and Validation of Small Molecule Compound

Published on: February 23, 2024

Area of Science:

  • Pharmacology
  • Genomics
  • Proteomics

Background:

  • Most drugs function by binding to gene products, but these interactions are often poorly understood.
  • Accurate knowledge of drug-target interactions is vital for effective therapeutics and avoiding clinical failures.
  • The rise of polypharmacy necessitates a deeper understanding of drugs engaging multiple targets.

Purpose of the Study:

  • To provide an overview of recent systematic approaches for characterizing bioactive compound targets.
  • To critically discuss the advancements in existing target identification technologies.
  • To offer a perspective on future innovative technologies for drug target discovery.

Main Methods:

  • Review of genetics-based approaches.
  • Review of proteomics-based approaches.
  • Review of expression profiling and bioinformatics procedures.

Main Results:

  • Several systematic methods for identifying drug targets have been developed.
  • Existing technologies for target characterization are continuously improving.
  • Emerging new-generation technologies promise further advancements.

Conclusions:

  • Systematic characterization of drug targets is essential for therapeutic development.
  • Advancements in various methodologies are enhancing our ability to identify drug targets.
  • Future innovations will likely revolutionize drug target discovery and validation.