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Related Experiment Video

Updated: Jun 17, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Small bowel transplantation.

Stephen Pollard1

  • 1Department of Transplantation, St. James University Hospital, Leeds, United Kingdom. spollard@doctors.org.uk

Clinics in Colon and Rectal Surgery
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

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Intestinal transplantation is a viable option for patients with intestinal failure when total parenteral nutrition is not sustainable. Advances in immunosuppression and antimicrobial therapy have improved outcomes, though graft dysfunction and sepsis remain challenges.

Area of Science:

  • Gastroenterology and Hepatology
  • Transplantation Surgery

Background:

  • Intestinal failure necessitates long-term management, often with total parenteral nutrition (TPN).
  • TPN can lead to complications like loss of venous access and severe cholestasis, limiting long-term survival.
  • Intestinal transplantation is emerging as a therapeutic alternative for select patients.

Purpose of the Study:

  • To review the current status and outcomes of intestinal transplantation.
  • To identify the challenges and advancements in the field.

Main Methods:

  • Review of current literature on intestinal transplantation.
  • Analysis of outcomes in larger centers focusing on immunosuppression and antimicrobial therapy.

Main Results:

Keywords:
Transplantationimmunosuppressionintestinetotal parenteral nutrition

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Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

Related Experiment Videos

Last Updated: Jun 17, 2026

Small Bowel Transplantation In Mice
36:30

Small Bowel Transplantation In Mice

Published on: August 20, 2007

Orthotopic Small Bowel Transplantation in Rats
09:16

Orthotopic Small Bowel Transplantation in Rats

Published on: November 6, 2012

Tissue Engineering of the Intestine in a Murine Model
08:45

Tissue Engineering of the Intestine in a Murine Model

Published on: December 1, 2012

  • Technical aspects are well-described, with improved outcomes due to advances in immunosuppression and antimicrobial therapy.
  • Graft monitoring and sepsis associated with graft dysfunction due to bacterial translocation are significant challenges.
  • Denervation, lymphatic disruption, graft-versus-host disease (GVHD), and nonphysiological venous drainage are not major problems.

Conclusions:

  • Intestinal transplantation is transitioning from experimental to therapeutic intervention.
  • It offers a potential solution for patients with intestinal failure unresponsive to TPN.
  • Further evaluation is needed to determine its role as a primary alternative versus a salvage procedure.