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Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...

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Related Experiment Video

Updated: Jun 17, 2026

Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

Colonic Crohn's disease.

Steven Mills1, Michael J Stamos

  • 1Division of Colon and Rectal Surgery, Department of Surgery, University of California, Irvine, Orange, CA 92868, USA. sdmills@uci.edu

Clinics in Colon and Rectal Surgery
|December 17, 2009
PubMed
Summary
This summary is machine-generated.

Crohn's disease is a gastrointestinal inflammatory condition. Surgery for colonic complications is reserved for specific cases, with segmental resection being suitable for select patients.

Keywords:
Crohn's diseasecolitiscolonsurgery

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Area of Science:

  • Gastroenterology
  • Colorectal Surgery

Background:

  • Crohn's disease is an idiopathic inflammatory condition affecting the gastrointestinal tract.
  • The colon is involved in approximately 60% of Crohn's disease cases.
  • Diagnosis relies on clinical, endoscopic, and pathological findings.

Purpose of the Study:

  • To review the management of colonic complications in Crohn's disease.
  • To discuss surgical indications and approaches for Crohn's disease involving the colon.

Main Methods:

  • Review of clinical presentation, diagnostic methods, and management strategies for colonic Crohn's disease.
  • Analysis of surgical indications and operative considerations for complications.

Main Results:

  • Surgical intervention is typically reserved for complications like hemorrhage, fulminant colitis, abscess, fistula, stricture, or malignancy.
  • Operative strategy is guided by clinical presentation and intraoperative findings.
  • Segmental resection is considered appropriate for specific patient cohorts.

Conclusions:

  • Management of colonic Crohn's disease requires a multidisciplinary approach.
  • Surgical intervention for Crohn's disease complications should be individualized.
  • The extent of resection in Crohn's disease surgery remains a subject of ongoing discussion.