Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Mismatch Repair01:20

Mismatch Repair

Organisms are capable of detecting and fixing nucleotide mismatches that occur during DNA replication. This sophisticated process requires identifying the new strand and replacing the erroneous bases with correct nucleotides. Mismatch repair is coordinated by many proteins in both prokaryotes and eukaryotes.
The Mutator Protein Family Plays a Key Role in DNA Mismatch Repair
The human genome has more than 3 billion base pairs of DNA per cell. Prior to cell division, that vast amount of genetic...
Mismatch Repair01:36

Mismatch Repair

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autologous cord blood in children with cerebral palsy: a review.

International journal of molecular sciences·2019
Same author

The role and potential of umbilical cord blood in an era of new therapies: a review.

Stem cell research & therapy·2015
Same author

Fetal-maternal interface: a chronicle of allogeneic coexistence.

Chimerism·2012
Same author

Umbilical cord blood for cardiovascular cell therapy: from promise to fact.

Annals of the New York Academy of Sciences·2012
Same author

PCR-based methodology for molecular microchimerism detection and quantification.

Experimental biology and medicine (Maywood, N.J.)·2008
Same author

Early hematopoietic microchimerism predicts clinical outcome after kidney transplantation.

Transplantation·2007
Same journal

Bacterial respiratory infections: advances in diagnostic strategies.

Expert review of molecular diagnostics·2026
Same journal

Artificial intelligence in molecular diagnostics for pandemic preparedness.

Expert review of molecular diagnostics·2026
Same journal

Navigating PD-L1 testing in immuno-oncology: analytical robustness, clinical validation, and the role of the VENTANA SP263 assay.

Expert review of molecular diagnostics·2026
Same journal

Extracellular vesicles as diagnostic and prognostic biomarkers in non-small cell lung cancer.

Expert review of molecular diagnostics·2026
Same journal

Explainable epigenetic aging clocks: an overview of existing AI models and approaches.

Expert review of molecular diagnostics·2026
Same journal

Neuro-axonal injury biomarker serum neurofilament light chain is associated with osteoarthritis: a dual-cohort study from NHANES and UK Biobank.

Expert review of molecular diagnostics·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

Should microchimerism turn into rejection prophylactics?

Josep-Maria Pujal1

  • 1Translational Research Laboratory, Institut Català d'Oncologia, Hospital Duran i Reynals, Avda Gran Via s/n, Km 2.7, 08907 L'Hospitalet de Llobregat, Barcelona, Spain. jmpujal@idibell.org

Expert Review of Molecular Diagnostics
|December 18, 2009
PubMed
Summary
This summary is machine-generated.

Chimerism occurs when non-self cells circulate in the body, potentially after transplants or pregnancy. This review explores hypotheses on circulating cells and their role in achieving tolerance through induced chimerism.

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Related Experiment Videos

Last Updated: Jun 17, 2026

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice
06:48

Transplantation of Tail Skin to Study Allogeneic CD4 T Cell Responses in Mice

Published on: July 25, 2014

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Area of Science:

  • Immunology
  • Cell Biology
  • Transplantation Science

Background:

  • Non-self cells can circulate within an individual following exposure to allogeneic sources.
  • This phenomenon, known as chimerism, can be transient or persistent.
  • Chimerism is observed in various contexts, including stem cell transplantation, pregnancy, and blood transfusions.

Purpose of the Study:

  • To review hypotheses concerning the existence, persistence, and function of circulating non-self cells.
  • To explore the historical understanding of chimerism since its initial description in mammals.
  • To discuss the application of artificially induced chimerism protocols for inducing tolerance.

Main Methods:

  • Literature review of scientific hypotheses and historical descriptions of chimerism.
  • Analysis of studies on circulating non-self cells in various physiological and pathological conditions.
  • Examination of research on induced chimerism protocols for tolerance induction.

Main Results:

  • Multiple hypotheses exist regarding the role and persistence of circulating non-self cells.
  • The concept of chimerism has evolved since its early observations in mammals.
  • Artificially induced chimerism shows potential for achieving transplantation tolerance.

Conclusions:

  • Circulating non-self cells represent a significant area of study in immunology and transplantation.
  • Understanding chimerism is crucial for advancing transplantation outcomes and tolerance induction.
  • Future research should focus on harnessing induced chimerism for therapeutic benefits.