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Related Experiment Videos

Ultrafast magnetic resonance imaging: diffusion and perfusion.

M E Moseley1, R Sevick, M F Wendland

  • 1Department of Radiology, University of California, San Francisco 94143.

Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes
|February 1, 1991
PubMed
Summary

Rapid echo-planar magnetic resonance imaging (MRI) detects early stroke effects by measuring decreased apparent diffusion coefficients within 1 hour of middle cerebral artery occlusion in cats. Contrast-enhanced imaging further identifies ischemic areas.

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Area of Science:

  • Neuroimaging
  • Medical Physics
  • Experimental Neurology

Background:

  • Echo-planar MRI enables rapid, noninvasive in vivo measurement of apparent diffusion coefficients.
  • Early detection of ischemic effects is crucial for timely intervention in stroke.
  • The feline middle cerebral artery occlusion model mimics human ischemic stroke.

Purpose of the Study:

  • To evaluate the utility of echo-planar MRI for assessing early ischemic changes.
  • To investigate the temporal dynamics of apparent diffusion coefficient changes post-MCA occlusion.
  • To assess the role of contrast-enhanced MRI in characterizing ischemic regions.

Main Methods:

  • Utilized rapid echo-planar MRI with diffusion-weighting (b values) to measure apparent diffusion coefficients.

Related Experiment Videos

  • Induced middle cerebral artery occlusion in a feline model.
  • Administered intravenous contrast agent (dysprosium-DTPA-BMA) to assess perfusion and vascular integrity.
  • Correlated MRI findings with vital staining for ischemic region identification.

    • Main Results:

    • Apparent diffusion coefficients significantly decreased in ischemic regions within 1 hour of MCA occlusion.
    • Diffusion-weighted images showed decreased signal intensity in early ischemic areas.
    • Contrast-enhanced MRI revealed relative hyperintensity in ischemic regions, indicating preserved vascular integrity or lack of contrast extravasation.
    • Signal loss from contrast was dose-dependent (40-80%).

    Conclusions:

    • Echo-planar MRI is a rapid and effective tool for detecting early ischemic changes in vivo.
    • Diffusion-weighted imaging can identify acute stroke within an hour of middle cerebral artery occlusion.
    • Contrast-enhanced MRI complements diffusion imaging by highlighting ischemic areas as regions of relative hyperintensity.