Related Experiment Video
Updated: Jun 17, 2026
10:27
Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
Published on: December 15, 2011
Hodgkin's lymphoma presenting with markedly elevated IgE: a case report.
1Division of Clinical Immunology & Allergy, Department of Medicine, McMaster University, Hamilton, ON, Canada. ellis.anne@gmail.com
Summary
Extremely high immunoglobulin E (IgE) levels can indicate a lymphoproliferative disorder like Hodgkin's lymphoma. This rare association warrants consideration in unexplained IgE elevations.
Area of Science:
- Clinical Immunology
- Hematology
- Oncology
Background:
- Markedly elevated immunoglobulin E (IgE) is rarely associated with lymphoproliferative disorders.
- This case highlights an unusual presentation of a malignant process.
Purpose of the Study:
- To report a case of significantly elevated IgE in a young adult.
- To discuss the association between high IgE levels and Hodgkin's lymphoma.
Main Methods:
- Case presentation of a 22-year-old female with extremely elevated IgE.
- Diagnostic workup included imaging (Chest X-ray, Gallium scan) and lymph node biopsy.
- Exclusion of atopy, infections, and parasitic causes.
Main Results:
- The patient was diagnosed with Hodgkin's lymphoma, nodular sclerosing subtype.
- Imaging revealed large anterior mediastinal masses with high gallium uptake.
Conclusions:
- Unexplained markedly elevated IgE can be a sign of malignancy, particularly lymphomas.
- Hodgkin's and Non-Hodgkin's lymphomas should be considered in the differential diagnosis of unexplained hyper-IgE states.
