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Related Experiment Video

Updated: May 17, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Characterizing the nasal microbiome using a nasal allergen challenge model.

Sophia Linton1, Calvin Sjaarda2, Lubnaa Hossenbaccus1

  • 1Division of Allergy & Immunology, Department of Medicine, Queen's University, Kingston, Ontario, Canada; Allergy Research Unit, Kingston Health Sciences Centre, Kingston General Hospital, Kingston, Ontario, Canada.

The Journal of Allergy and Clinical Immunology
|May 15, 2026
PubMed

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Summary

Allergen exposure did not alter the nasal microbiome in allergic rhinitis patients. Host factors like IgE levels and sex, not allergen challenge, influenced nasal microbial composition.

Area of Science:

  • Microbiology
  • Immunology
  • Allergology

Background:

  • The nasal microbiome's role in allergic rhinitis (AR) after allergen exposure is unclear.
  • Understanding these dynamics can offer insights into AR pathophysiology.

Purpose of the Study:

  • To assess nasal microbiome alterations post-nasal allergen challenge (NAC) in AR patients versus controls.
  • To investigate the impact of ragweed pollen extract on nasal microbial communities.

Main Methods:

  • 19 allergic and 12 non-allergic participants underwent NAC.
  • Nasal secretions were collected at baseline and 6, 24, 48 hours post-challenge.
  • 16S rRNA sequencing analyzed microbial composition; IgE levels and S. aureus carriage were assessed.
Keywords:
Allergic rhinitisIgEnasal allergen challengenasal microbiomeragweed

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Last Updated: May 17, 2026

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples
11:54

Absorption of Nasal and Bronchial Fluids: Precision Sampling of the Human Respiratory Mucosa and Laboratory Processing of Samples

Published on: January 21, 2018

Murine Model of Allergen Induced Asthma
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Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
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Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay

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Main Results:

  • Nasal microbiome composition varied by sex and S. aureus carriage, but not allergic status or NAC exposure.
  • Genus-level differences (Streptococcus, Veillonella) appeared 24-48 hours post-challenge.
  • Higher IgE levels correlated with distinct microbial profiles and reduced diversity.

Conclusions:

  • The nasal microbiome remained stable after acute allergen exposure, despite clinical AR symptoms.
  • Host factors (IgE, sex, S. aureus) significantly influenced nasal microbial composition.