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A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
[Acute renal failure in premature neonates]
Aleksandra Doronjski1, Vesna Stojanović, Slobodan Spasojević
1Institut za decu i omladinu Vojvodine, Pedijatrijska klinika, Odeljenje intenzivne nege, Novi Sad, Srbija. adoronjski@yahoo.co.uk
Vojnosanitetski Pregled
|December 19, 2009
Summary
Acute renal failure (ARF) affects 25% of premature neonates, particularly those with low birth weight and extreme immaturity. Early identification of risk factors like low birth weight is crucial for managing ARF in this vulnerable population.
Area of Science:
- Neonatalogy
- Pediatric Nephrology
- Critical Care Medicine
Context:
- Hemodynamic stress is a primary cause of acute renal failure (ARF) in premature neonates.
- The incidence of ARF in premature neonates ranges from 8% to 24%.
Purpose:
- To determine the frequency of ARF in premature neonates.
- To assess the impact of ARF on the survival rates of premature neonates.
Summary:
- A retrospective study analyzed 114 premature neonates, diagnosing ARF in 25% (16/65) based on serum creatinine and urea levels.
- Premature neonates with ARF exhibited significantly lower gestational age, birth weight, and systolic blood pressure compared to those without ARF.
- Low birth weight (<1500g) showed the highest sensitivity (75%) for predicting ARF, while gestational age <28 weeks, sepsis, and intracranial hemorrhage demonstrated high specificity.
Impact:
- ARF in premature neonates is associated with increased mortality (25% vs. 10% in non-ARF cases).
- Complete renal function recovery was observed in survivors, highlighting the importance of timely management.
- Meticulous fluid and electrolyte balance is essential for managing ARF in premature neonates, especially those with low birth weight and extreme immaturity.
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