Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 17, 2026

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
09:34

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

A smart glycol-directed nanodevice from rationally designed macroporous materials.

Kun Qian1, Jingjing Wan, Xiaodan Huang

  • 1Department of Chemistry and Institute of Biomedical Sciences, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, PR China.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|December 22, 2009
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Carbon Nanostructure-Initiator Mass Spectrometry for Metabolic Biomarker Detection of Prediabetes.

Analytical chemistry·2026
Same author

Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy.

International journal of molecular medicine·2026
Same author

Therapeutic applications and prospects of inhalable mesoporous silica nanoparticles in pulmonary diseases.

Nanoscale·2026
Same author

Coordination orientation isomerism boosting concerted hydrogen peroxide photosynthesis.

Nature communications·2026
Same author

Hollow micro-/nanostructures for enhanced pathogen theranostics.

Chemical Society reviews·2026
Same author

Nanoporous Materials in Biomedical Research: Progress and Potential.

International journal of nanomedicine·2026

A novel nanodevice efficiently detects glycoproteins using functionalized silica foam. This integrated system simplifies glycoprotein isolation and analysis, offering a significant advantage over traditional methods.

Area of Science:

  • Materials Science
  • Biochemistry
  • Nanotechnology

Background:

  • Glycoprotein detection is crucial in diagnostics and research.
  • Conventional methods for glycoprotein isolation are often time-consuming and multi-step.
  • There is a need for efficient and selective glycoprotein detection and enrichment techniques.

Purpose of the Study:

  • To develop a smart nanodevice for highly efficient and selective glycoprotein detection.
  • To integrate multiple functionalized materials for simultaneous protein digestion and glycopeptide isolation.
  • To overcome limitations of conventional multi-procedure techniques.

Main Methods:

  • Fabrication of a polyfunctional nanodevice using macroporous silica foam (MOSF).
  • Functionalization of MOSF with boron species (B-MOSF) and amino groups (NH(2)-MOSF).

More Related Videos

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

Related Experiment Videos

Last Updated: Jun 17, 2026

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold
09:34

Microfluidic Synthesis of Microgel Building Blocks for Microporous Annealed Particle Scaffold

Published on: June 16, 2022

Interlinked Macroporous 3D Scaffolds from Microgel Rods
07:32

Interlinked Macroporous 3D Scaffolds from Microgel Rods

Published on: June 16, 2022

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization
06:26

Synthesis of Stimuli-responsive Nanogels using Aqueous One-step Crosslinking and Co-nanopolymerization

Published on: January 24, 2025

  • Integration of MOSF, B-MOSF, and NH(2)-MOSF for chemo-affinity and charge-based purification.

    • Main Results:

    • The nanodevice exhibits a macroporous structure facilitating enzymatic reactions.
    • Selective isolation and enrichment of glycopeptides via chemo-affinity with boronic acid.
    • Simultaneous protein digestion and glycopeptide isolation achieved in a single step.

    Conclusions:

    • The developed nanodevice offers a highly efficient and selective platform for glycoprotein detection.
    • This integrated approach significantly simplifies and accelerates the analysis of glycoproteins.
    • The smart nanodevice presents a promising alternative to conventional, laborious methods.