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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
Published on: May 21, 2015
The implications of autoimmunity and pregnancy
Andrea T Borchers1, Stanley M Naguwa, Carl L Keen
1Division of Rheumatology, Allergy and Clinical Immunology, University of California at Davis School of Medicine, 451 Health Sciences Drive, Suite 6510, Davis, CA 95616, USA.
Pregnancy with autoimmune diseases is safer than previously thought, especially when planned during stable disease periods. Advances in treatment improve outcomes for both mother and child, though risks remain.
Area of Science:
- Reproductive immunology and epidemiology
- Maternal-fetal medicine
- Autoimmune disease management
Background:
- Autoimmunity can impact reproduction, historically posing high risks for pregnancy.
- Recent data show improved outcomes with advanced treatments and planned pregnancies.
Purpose of the Study:
- To review epidemiological evidence on pregnancy in autoimmune diseases.
- To assess risks and outcomes for mother and child.
- To explore the impact of hormones and microchimerism.
Main Methods:
- Review of epidemiological studies on pregnancy and autoimmune diseases.
- Focus on anti-phospholipid syndrome, SLE, MS, RA, and T1D.
- Analysis of maternal effects, fetal risks, and therapeutic advancements.
Main Results:
- Planned pregnancies during stable disease yield healthier outcomes.
- Autoimmune diseases still pose high risks, including exacerbations and perinatal issues.
- Fetal mortality is a key concern in anti-phospholipid syndrome.
Conclusions:
- Pregnancy outcomes in autoimmune diseases have improved significantly.
- Careful management and disease stability are crucial for successful pregnancies.
- Further research is needed on hormonal influences and microchimerism.
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