Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of the Lymphatic System01:15

Development of the Lymphatic System

The development of lymphatic tissues and vessels in embryonic life begins around the fifth week. These structures originate from the mesoderm layer, with lymph sacs emerging from developing veins.
The first lymph sacs to form are the paired jugular lymph sacs located at the junction of the internal jugular and subclavian veins. From these sacs, lymphatic capillary plexuses extend to the thorax, upper limbs, neck, and head, eventually forming lymphatic vessels. Each jugular lymph sac maintains a...
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular spaces.
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Detailed Structure and Function of Lymph Nodes01:23

Detailed Structure and Function of Lymph Nodes

Lymph nodes are bean-shaped structures that cluster along the lymphatic vessels in the inguinal, axillary, and cervical regions. Each node is divided into compartments by a capsule that extends trabeculae inward.
From a histological perspective, lymph nodes can be split into two main areas: the superficial cortex and the deep medulla. The outer cortex is populated by dendritic cells, macrophages, and B lymphocytes, which are densely packed into follicles. When these B-lymphocytes are presented...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polypoid Acral Amelanotic Melanoma: A Rare Variant Treated with Wide and Deep Surgical Excision.

Acta dermatovenerologica Croatica : ADC·2026
Same author

Alopecia areata: current concepts.

Wiener klinische Wochenschrift·2026
Same author

Acral acanthotic anomaly: a comprehensive review.

Italian journal of dermatology and venereology·2026
Same author

Vincent A. Cipollaro MD (1931-2025): A Foundational Pillar in International Dermatology.

International journal of dermatology·2026
Same author

Cutaneous Amyloidosis: An Updated Approach Focusing on Macular Amyloidosis.

Dermatology (Basel, Switzerland)·2026
Same author

Keratin-TMAO dressing accelerates full-thickness skin wound healing in diabetic rats via M2-macrophage polarization and the activation of PI3K/AKT/mTOR signaling pathway.

International journal of biological macromolecules·2025
Same journal

Successful treatment of dupilumab-induced rosacea with upadacitinib in a patient with atopic dermatitis.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2026
Same journal

Types of phacomatosis pigmentovascularis associated with nevus cesius.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2026
Same journal

A biomarker-guided therapeutic map for alopecia: in vivo evidence and clinical implications.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2026
Same journal

Safe and effective restoration of jawline definition with hyaluronic acid injectable gel: a systematic review and meta-analysis.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2026
Same journal

Evaluation of the effects of cinobufagin on G361 melanoma cells and a comparison with paclitaxel.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2026
Same journal

Acidity difference and skin Staphylococcus spp. colonization in preterm and term newborns.

Acta dermatovenerologica Alpina, Pannonica, et Adriatica·2026
See all related articles

Related Experiment Video

Updated: Jun 17, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Zosteriform lymphangioma circumscriptum.

Gopal A Patel1, Robyn D Siperstein, Gangaram Ragi

  • 1Dermatology, New Jersey Medical School, 185 South Orange Avenue, Newark, New Jersey 07103-2714, USA.

Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|January 1, 2010
PubMed
Summary
This summary is machine-generated.

Lymphangioma circumscriptum (LC) presents as skin vesicles. This report details an uncommon verruciform, zosteriform presentation of LC, highlighting its varied clinical appearance.

Related Experiment Videos

Last Updated: Jun 17, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Area of Science:

  • Dermatology
  • Vascular Malformations

Background:

  • Lymphangioma circumscriptum (LC) is a benign vascular malformation characterized by superficial lymphatic vessel dilation.
  • It typically manifests as clusters of translucent vesicles on the skin and subcutaneous tissue.
  • LC can be mistaken for other dermatological conditions, necessitating accurate diagnosis.

Observation:

  • The study describes a rare presentation of lymphangioma circumscriptum.
  • This specific case exhibited a verruciform (wart-like) and zosteriform (following a nerve distribution) morphology.
  • The vesicles varied in size and color, appearing pink, red, or black.

Findings:

  • The unusual verruciform, zosteriform pattern of LC is documented.
  • This presentation expands the known clinical spectrum of lymphangioma circumscriptum.
  • Differential diagnosis considerations include metastatic carcinoma, lymphangiectasis, and herpes zoster.

Implications:

  • Recognizing this atypical presentation is crucial for correct diagnosis and management of lymphangioma circumscriptum.
  • This case underscores the importance of considering rare variants in dermatological diagnoses.
  • Further understanding of LC's diverse manifestations can improve patient outcomes.