Related Experiment Video
Updated: Jun 17, 2026
Isolation of Human Mesenchymal Stem Cells and their Cultivation on the Porous Bone Matrix
Published on: February 9, 2015
Mesenchymal stem cells and bovine bone mineral in sinus lift procedures--an experimental study in sheep
Sebastian Sauerbier1, Kerstin Stubbe, Michele Maglione
1Department of Oral and Maxillofacial Surgery, Albert-Ludwigs-University, Freiburg, Germany. sebastian.sauerbier@uniklinik-freiburg.de
Introduction:
New reconstructive and less invasive methods have been searched to optimize bone formation and osseointegration of dental implants in maxillary sinus augmentation.
Purpose:
The aim of the presented ovine split-mouth study was to compare bovine bone mineral (BBM) alone and in combination with mesenchymal stem cells (MSCs) regarding their potential in sinus augmentation.
Material And Methods:
Bilateral sinus floor augmentations were performed in six adult sheep. BBM and MSCs were placed into the test side and only BBM in the contra-lateral control side of each sheep. Animals were sacrificed after 8 and 16 weeks. Augmentation sites were analyzed by computed tomography, histology, and histomorphometry.
Results:
The initial volumes of both sides were similar and did not change significantly with time. A tight connection between the particles of BBM and the new bone was observed histologically. Bone formation was significantly (p = 0.027) faster by 49% in the test sides.
Conclusion:
The combination of BBM and MSCs accelerated new bone formation in this model of maxillary sinus augmentation. This could allow early placement of implants.
