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Updated: Jun 17, 2026
07:54
Drug-Induced Sleep Endoscopy (DISE) with Target Controlled Infusion (TCI) and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
[Opioids and sleep disordered breathing].
1Service de pneumologie et Centre d'investigation et de recherche sur le sommeil, (CIRS), CHUV, 1011 Lausanne.
Revue Medicale Suisse
|January 8, 2010
Summary
Chronic opioid use significantly increases the risk of sleep disordered breathing, often requiring advanced ventilation. Continuous positive airway pressure is typically ineffective for these patients.
Area of Science:
- Pulmonology
- Sleep Medicine
- Pharmacology
Context:
- Increased medical use of chronic opioids in Switzerland.
- Opioid-induced sleep disordered breathing (OISDB) affects 70% of chronic users.
- Nocturnal breathing disorders are more prevalent in older patients with COPD or obstructive sleep apnea.
Purpose:
- To highlight the prevalence and characteristics of sleep disordered breathing in chronic opioid users.
- To discuss the limitations of continuous positive airway pressure (CPAP) in treating OISDB.
- To emphasize the need for advanced ventilatory support in managing OISDB.
Summary:
- Opioid use is linked to a high incidence of sleep disordered breathing, characterized by ataxic breathing, central apneas, and hypopneas.
- Standard CPAP treatment is often ineffective for OISDB.
- Advanced ventilation strategies, including bilevel ventilation and adaptive servoventilation, are frequently necessary.
Impact:
- OISDB poses a significant clinical challenge, necessitating tailored treatment approaches.
- Understanding OISDB is crucial for managing chronic pain patients on opioid therapy.
- This research underscores the importance of respiratory monitoring in chronic opioid users, particularly older individuals with comorbidities.
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