Related Experiment Video
Updated: Jun 17, 2026

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform
Published on: May 10, 2024
[Cardiotoxicity induced by 5-fluorouracil or capecitabine]
Søren Astrup Jensen1, Lene Baeksgaard, Lone Nørgaard Petersen
1Onkologisk Afdeling 5073, Rigshospitalet, DK-2100 København Ø, Denmark. soren.a.jensen@mail.tele.dk
Abstract:
5-fluorouracil and capecitabine have significant antineoplastic activity towards various solid tumors. Cardiotoxicity causing angina, arrhythmia and infarction are serious adverse events associated with these agents. The pathogenesis is discussed and symptoms of cardiotoxicity, intervention with nitroglycerine and risk factors as cardiac comorbidity are described. Following cardiotoxicity, lack of alternative active agents may provide grounds to rechallenge with 5-FU. In this situation, dose-modified 5-FU-based chemotherapy supported by medical antiangina prevention is feasible.
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