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Lipopolysaccharide and TNF-alpha modify adenosine A(2A) receptor expression and function in equine monocytes

Wan-chun Sun1, Londa J Berghaus, James N Moore

  • 1Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, United States.

Veterinary Immunology and Immunopathology
|January 9, 2010
PubMed
Summary

Pro-inflammatory substances like LPS and TNF-alpha increase adenosine A(2A) receptors in horse monocytes. This enhances the anti-inflammatory effects of A(2A) receptor agonists, suggesting their therapeutic potential for equine inflammatory conditions.

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