Related Experiment Video
Updated: Jun 17, 2026
Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Coronary score adds prognostic information for patients with acute coronary syndrome
Gang Huang1, Jiang-Long Zhao, Huaan Du
1Department of Cardiology, The Second People's Hospital of Chengdu, China.
Insights
The Gensini score is a better predictor of cardiovascular risk in acute coronary syndrome (ACS) patients than the Leaman or ACC/AHA scores. This finding helps identify high-risk patients for better management of major adverse cardiovascular events (MACE).
Area of Science:
- Cardiology
- Clinical Risk Assessment
- Medical Scoring Systems
Background:
- Acute coronary syndrome (ACS) poses significant cardiovascular risk.
- Accurate prognostic scoring is crucial for managing ACS patients.
- Existing coronary scoring systems require evaluation for their predictive value in ACS.
Purpose of the Study:
- To compare the prognostic value of three coronary scores: Gensini, Leaman, and American College of Cardiology/American Heart Association (ACC/AHA).
- To assess the association of these scores with major adverse cardiovascular events (MACE) in ACS patients.
Main Methods:
- A cohort of 958 consecutive ACS patients was followed up for MACE.
- Cox regression analysis was used to evaluate the association of Gensini and Leaman scores with MACE over different time points.
- Logistic regression analysis assessed the association of Gensini, Leaman, and ACC/AHA scores with cardiogenic death.
Main Results:
- The Gensini score was significantly associated with 90-day, 6-month, 1-year, and overall follow-up MACE.
- The Leaman score was significantly associated with 90-day, 6-month, and 1-year MACE.
- Gensini, Leaman, and ACC/AHA scores were all associated with cardiogenic death.
Conclusions:
- The Gensini score demonstrates superior prognostic value for cardiovascular risk compared to the Leaman and ACC/AHA scores in ACS patients.
- These findings support the use of the Gensini score for improved risk stratification in ACS.
Background:
The aim of the present study was to explore the association of 3 coronary scores with major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS).
Methods And Results:
The 958 consecutive patients with ACS were followed up until either MACE or 31(st) December 2008 occurred; 257 patients reached clinical endpoints. Cox regression analysis demonstrated that the Gensini score was associated with 90-day MACE (relative risk (RR) 1.021, P=0.004), 6-month MACE (RR 1.021, P<0.001), 1-year MACE (RR 1.017, P=0.002), and MACE during follow-up (RR 1.010, P=0.040). Leaman score was associated with 90-day MACE (RR 1.094, P=0.014), 6-month MACE (RR 1.098, P=0.002), and 1-year MACE (RR 1.074, P=0.009). The logistic regression analysis demonstrated that the Gensini score (odds ratio (OR) 1.037, P=0.001), Leaman score (OR 1.165, P=0.007) and American College of Cardiology/American Heart Association (ACC/AHA) score (OR 1.235, P=0.025) were all associated with cardiogenic death.
Conclusions:
The Gensini score provides more valuable prognostic information on cardiovascular risk than either the Leaman or ACC/AHA score in patients with ACS.
Related Concept Videos
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:25Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT
01:30Acute Coronary Syndrome I: Introduction
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:28Acute Coronary Syndrome IV: Interprofessional Care
01:26Acute Coronary Syndrome V: Nursing Management