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Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery (SALLI) MRI in Rats
Published on: July 19, 2013
Cardiac sarcoidosis evaluated by multimodality imaging.
International Journal of Cardiology
|January 12, 2010
Summary
This study highlights active cardiac sarcoidosis in a patient with sarcoidosis presenting with new-onset heart block. Advanced imaging confirmed inflammation in the left ventricle, leading to corticosteroid treatment.
Area of Science:
- Cardiology
- Oncology
- Immunology
Background:
- Sarcoidosis is a multisystem inflammatory disease that can affect the heart.
- Cardiac sarcoidosis diagnosis can be challenging, especially in asymptomatic patients.
- Early detection and treatment are crucial to prevent cardiac dysfunction and adverse outcomes.
Observation:
- A 62-year-old female with a history of sarcoidosis presented with new-onset right bundle-branch block.
- Echocardiography revealed left ventricular wall thinning and hypokinesis.
- ECG-gated CT and cardiac MRI showed abnormalities suggestive of fibrosis or inflammation in the basal left ventricle.
Findings:
- 18F-FDG PET demonstrated increased uptake in the affected LV region, indicating active inflammation.
- T2-weighted MRI also suggested inflammation.
- 67-Gallium scintigraphy showed no significant uptake.
Implications:
- This case underscores the utility of integrated imaging modalities, particularly 18F-FDG PET and cardiac MRI, in diagnosing active cardiac sarcoidosis.
- Prompt corticosteroid therapy can manage inflammation and potentially improve cardiac function.
- Increased awareness and diagnostic vigilance for cardiac involvement in sarcoidosis patients are warranted.
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