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[Microbial associations defecting in children with chronic pyelonephritis]

Iu L Naboka, L I Vasil'eva, M I Kogan

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 13, 2010
    PubMed

    Insights

    Bacterial and viral infections frequently co-occur in children with obstructive pyelonephritis. This mixed infection highlights the need for comprehensive diagnostic and treatment strategies for pediatric kidney infections.

    Area of Science:

    • Pediatric Nephrology
    • Microbiology
    • Virology

    Context:

    • Pyelonephritis is a significant kidney infection in children.
    • Obstructive pyelonephritis presents unique diagnostic and therapeutic challenges.
    • Understanding microbial and viral co-infections is crucial for effective management.

    Purpose:

    • To investigate the detection rates of various bacteria and viruses in children with pyelonephritis.
    • To identify common microbial and viral associations in pediatric pyelonephritis.
    • To compare infection patterns in children with chronic secondary pyelonephritis versus those undergoing nephrectomy.

    Summary:

    • A study of 274 children (5-10 years) with pyelonephritis revealed high rates of bacterial-viral co-infection.
    • In chronic secondary pyelonephritis, mixed bacterial infections (e.g., staphylococci, Escherichia, Mycoplasma) and herpesviruses/papillomaviruses were common.
    • In the nephrectomy group, bacterial and viral presence varied between pre-operative urine, operative urine, and renal biopsy samples, with viruses detected in biopsies even when absent in operative urine.

    Impact:

    • Findings underscore the prevalence of bacterial-viral mixed infections in pediatric obstructive pyelonephritis.
    • Results emphasize the importance of considering both bacterial and viral pathogens in diagnosis and treatment.
    • This research informs clinical practice for managing complex pediatric kidney infections.
    Abstract

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