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Published on: October 18, 2019
[Microbial associations defecting in children with chronic pyelonephritis].
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|January 13, 2010
Summary
Bacterial and viral infections frequently co-occur in children with obstructive pyelonephritis. This mixed infection highlights the need for comprehensive diagnostic and treatment strategies for pediatric kidney infections.
Area of Science:
- Pediatric Nephrology
- Microbiology
- Virology
Context:
- Pyelonephritis is a significant kidney infection in children.
- Obstructive pyelonephritis presents unique diagnostic and therapeutic challenges.
- Understanding microbial and viral co-infections is crucial for effective management.
Purpose:
- To investigate the detection rates of various bacteria and viruses in children with pyelonephritis.
- To identify common microbial and viral associations in pediatric pyelonephritis.
- To compare infection patterns in children with chronic secondary pyelonephritis versus those undergoing nephrectomy.
Summary:
- A study of 274 children (5-10 years) with pyelonephritis revealed high rates of bacterial-viral co-infection.
- In chronic secondary pyelonephritis, mixed bacterial infections (e.g., staphylococci, Escherichia, Mycoplasma) and herpesviruses/papillomaviruses were common.
- In the nephrectomy group, bacterial and viral presence varied between pre-operative urine, operative urine, and renal biopsy samples, with viruses detected in biopsies even when absent in operative urine.
Impact:
- Findings underscore the prevalence of bacterial-viral mixed infections in pediatric obstructive pyelonephritis.
- Results emphasize the importance of considering both bacterial and viral pathogens in diagnosis and treatment.
- This research informs clinical practice for managing complex pediatric kidney infections.
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