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Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors
Published on: February 7, 2018
Current status of measuring oxidative stress.
Beniamino Palmieri1, Valeriana Sblendorio
1Department of General Surgery and Surgical Specialties, Surgical Clinic, University of Modena and Reggio Emilia, Modena, Italy. palmieri@unimo.it
Methods in Molecular Biology (Clifton, N.J.)
|January 15, 2010
Summary
Oxidative stress, an imbalance between free radicals and antioxidant capacity, often goes undetected due to a lack of routine screening. Early detection through available tests is crucial for managing this condition.
Area of Science:
- Biochemistry
- Clinical Medicine
- Health Sciences
Background:
- Oxidative stress is an imbalance between reactive oxygen species (ROS) production and antioxidant capacity (AC).
- Despite growing awareness, oxidative stress screening is not routine, leading to delayed or unaddressed cases.
- Patients often receive antioxidant supplements without assessing their actual need or depleted antioxidant levels.
Purpose of the Study:
- To highlight the critical need for routine oxidative stress screening and monitoring.
- To emphasize the diagnostic gap in assessing free radical damage and antioxidant capacity.
- To promote the adoption of available testing methods for oxidative stress.
Main Methods:
- Discusses the imbalance between free radicals (ROS) and antioxidant capacity (AC).
- Highlights the lack of routine diagnostic tests for oxidative stress.
- Mentions the increasing availability of photometric test kits for small laboratories.
Main Results:
- Oxidative stress often presents with no discernible symptoms, making early detection challenging.
- The relationship between ROS production and AC is complex and not always apparent.
- Photometric test kits for oxidative stress assessment are becoming more accessible.
Conclusions:
- Routine screening for oxidative stress is essential for timely intervention.
- Available testing methods can aid in assessing free radical damage and antioxidant status.
- Integrating oxidative stress monitoring into healthcare practices is recommended.
