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Experimental Infection with Listeria monocytogenes as a Model for Studying Host Interferon-γ Responses
Published on: November 16, 2016
Clinical Use of Interferon-gamma
Catriona H T Miller1, Stephen G Maher, Howard A Young
1Center for Cancer Research, Cancer and Inflammation Program, Laboratory of Experimental Immunology, National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.
Annals of the New York Academy of Sciences
|January 16, 2010
Summary
Interferon gamma (IFN-gamma), a crucial cytokine for immune responses, has demonstrated therapeutic potential since early clinical trials in 1986. Its antitumor and anti-infection activities have led to diverse clinical applications reviewed herein.
Area of Science:
- Immunology
- Cytokine Biology
- Clinical Therapeutics
Background:
- Interferon gamma (IFN-gamma) is a pleiotropic cytokine vital for immune cell function.
- It plays a key role in both innate and adaptive immunity.
- Early clinical trials commenced in 1986 to assess its therapeutic value.
Purpose of the Study:
- To review the therapeutic potential of IFN-gamma.
- To summarize its antitumor and anti-infection activities.
- To explore its wide-ranging clinical indications.
Main Methods:
- Review of early clinical trials.
- Analysis of pharmacological and tolerability data.
- Systematic evaluation of antitumor and anti-infection effects.
Main Results:
- IFN-gamma exhibits significant antitumor and anti-infection properties.
- Initial studies confirmed its tolerability and pharmacological profile.
- Extensive clinical use has been established over two decades.
Conclusions:
- IFN-gamma has proven therapeutic efficacy.
- Its applications have expanded significantly since initial trials.
- This review highlights its established role in various clinical settings.
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