Related Experiment Video

Updated: Jun 17, 2026

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

A case-control association analysis of CABIN1 with schizophrenia in a Japanese population

Yuichiro Watanabe1, Ayako Nunokawa, Naoshi Kaneko

  • 1Department of Psychiatry, Niigata University Graduate School of Medical and Dental Sciences, Asahimachidori-ichibancho, Chuo-ku, Niigata, Japan. yuichiro@med.niigata-u.ac.jp

Journal of Human Genetics
|January 16, 2010
PubMed

Insights

This study investigated the association between the CABIN1 gene and schizophrenia in Japanese individuals. The findings indicate that CABIN1 does not appear to increase schizophrenia susceptibility in this population.

Area of Science:

  • Neuroscience
  • Psychiatric Genetics

Background:

  • Calcineurin (CN) signaling is implicated in schizophrenia pathogenesis.
  • The CN-binding protein 1 (CABIN1) gene, located at a schizophrenia susceptibility locus (22q11.23), is a candidate gene.
  • CABIN1's role in schizophrenia vulnerability requires investigation.

Purpose of the Study:

  • To determine if CABIN1 gene variations are associated with schizophrenia risk.
  • To assess CABIN1 as a functional and positional candidate gene for schizophrenia.

Main Methods:

  • A case-control association study was performed.
  • 11 tagging single nucleotide polymorphisms (SNPs) in the CABIN1 gene were analyzed.
  • The study included 1193 Japanese subjects.

Main Results:

  • No statistically significant association was found between CABIN1 and schizophrenia.
  • The analyzed SNPs did not show a link to increased schizophrenia susceptibility.

Conclusions:

  • The CABIN1 gene may not contribute to schizophrenia risk in the Japanese population.
  • Further research may be needed to explore other genetic factors in schizophrenia.

More Related Videos

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Bias in Epidemiological Studies01:29

Bias in Epidemiological Studies

Biases can arise at various stages of research, from study design and data collection to analysis and interpretation. Recognizing and addressing these biases is essential to ensure the validity and reliability of epidemiological findings.Broadly speaking, biases in epidemiology fall into three main categories: selection bias, information bias, and confounding. A more detailed description of possible biases is: