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New neo-clerodane diterpenoids from Scutellaria barbata with cytotoxic activities
Sheng-Jun Dai1, Gui-Wu Qu, Qun-Ying Yu
1School of Pharmaceutical Science, Yantai University, Yantai 264005, PR China. daishengjun_9@hotmail.com
Fitoterapia
|January 19, 2010
Abstract:
Two new neo-clerodane diterpenoids have been isolated from the whole plant of Scutellaria barbata D. Don, and their structures were established by detailed spectral analyses as scutehenanine H (1) and 6-(2,3-epoxy-2-isopropyl-n-propoxyl)barbatin C (2). In vitro, the isolated two new compounds showed significant cytotoxic activities against three human cancer lines, and gave IC(50) values in the range OF 2.0-4.2 μΜ.