Related Experiment Video
Updated: Jun 17, 2026

Assessing Rat Diaphragm Motor Unit Connectivity Outcome Measures as Quantitative Biomarkers of Phrenic Motor Neuron Degeneration and Compensation
Published on: April 19, 2024
Pacing electrode selection in a quadripolar left heart lead determines presence or absence of phrenic nerve
Bernard Thibault1, Edward Karst, Kyungmoo Ryu
1Montreal Heart Institute, 5000, Belanger Street East, Montreal, QC, Canada. b_thibault@icm-mhi.com
Abstract:
A 60-year-old ischaemic patient presented for routine cardiac resynchronization therapy (CRT)-D implantation. An investigational quadripolar left ventricular lead was placed in the posterolateral vein. Phrenic nerve stimulation (PNS) was observed, but it occurred during pacing from only one of the four electrodes. A lead with multiple pacing electrodes is a potential alternative to physical adjustment of the lead or discontinuing CRT when PNS occurs.
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