Related Experiment Video
Updated: Jun 17, 2026

Quantification of Information Encoded by Gene Expression Levels During Lifespan Modulation Under Broad-range Dietary Restriction in C. elegans
Published on: August 16, 2017
Mathematical philology: entropy information in refining classical texts' reconstruction, and early philologists'
John L Cisne1, Robert M Ziomkowski, Steven J Schwager
1Department of Earth and Atmospheric Sciences, Cornell University, Ithaca, New York, USA. john.cisne@cornell.edu
Abstract:
Philologists reconstructing ancient texts from variously miscopied manuscripts anticipated information theorists by centuries in conceptualizing information in terms of probability. An example is the editorial principle difficilior lectio potior (DLP): in choosing between otherwise acceptable alternative wordings in different manuscripts, "the more difficult reading [is] preferable." As philologists at least as early as Erasmus observed (and as information theory's version of the second law of thermodynamics would predict), scribal errors tend to replace less frequent and hence entropically more information-rich wordings with more frequent ones. Without measurements, it has been unclear how effectively DLP has been used in the reconstruction of texts, and how effectively it could be used. We analyze a case history of acknowledged editorial excellence that mimics an experiment: the reconstruction of Lucretius's De Rerum Natura, beginning with Lachmann's landmark 1850 edition based on the two oldest manuscripts then known. Treating words as characters in a code, and taking the occurrence frequencies of words from a current, more broadly based edition, we calculate the difference in entropy information between Lachmann's 756 pairs of grammatically acceptable alternatives. His choices average 0.26+/-0.20 bits higher in entropy information (95% confidence interval, P = 0.005), as against the single bit that determines the outcome of a coin toss, and the average 2.16+/-0.10 bits (95%) of (predominantly meaningless) entropy information if the rarer word had always been chosen. As a channel width, 0.26+/-0.20 bits/word corresponds to a 0.790.79(+0.09) (-0.15) likelihood of the rarer word being the one accepted in the reference edition, which is consistent with the observed 547/756 = 0.72+/-0.03 (95%). Statistically informed application of DLP can recover substantial amounts of semantically meaningful entropy information from noise; hence the extension copiosior informatione lectio potior, "the reading richer in information [is] preferable." New applications of information theory promise continued refinement in the reconstruction of culturally fundamental texts.
Related Concept Videos
Entropy
Entropy
When an ideal gas expands isothermally, the disorder in the gas increases. From the molecular perspective, the gas molecules have more volume to move around in.
Consider an infinitesimal step in the expansion, which...
Entropy Changes Accompanying Specific Processes
Entropy and the Second Law of Thermodynamics
The relation between entropy and disorder can be illustrated with the example of the phase change of ice to water. In ice, the molecules are located at specific sites giving a solid state, whereas, in a liquid form, these molecules are much freer to move. The molecular arrangement has therefore become more randomized. Although the change in average...
Entropy and the Second Law of Thermodynamics
Absolute Entropies and the Third Law of Thermodynamics
