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Updated: Jun 16, 2026
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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Summary
Chronic kidney disease (CKD) prevalence is rising globally. This review suggests age-related kidney decline may stem from vascular aging, proposing "Cardio-Kidney-Damage" (C-K-D) as a more accurate definition.
Area of Science:
- Nephrology
- Cardiology
- Geriatrics
- Vascular Medicine
Background:
- Global increase in Chronic kidney disease (CKD) prevalence.
- Debate exists whether this reflects true incidence increase or population aging.
- Age-related kidney function decline is often assumed physiological.
Purpose of the Study:
- Reconcile differing views on CKD prevalence increase.
- Investigate the link between vascular aging and kidney function decline.
- Propose a new definition for age-related kidney disease.
Main Methods:
- Literature review and synthesis of existing research.
- Analysis of the relationship between vascular aging, atherosclerosis, and kidney health.
- Conceptual re-framing of age-related kidney disease.
Main Results:
- Age-related kidney function decline may not be purely physiological.
- Diffuse vascular aging and atherosclerosis significantly impact kidney function.
- These vascular changes affect multiple organs, including the kidneys.
Conclusions:
- Age-related kidney disease is potentially a manifestation of systemic vascular aging.
- The term Cardio-Kidney-Damage (C-K-D) is proposed as a more fitting descriptor.
- This reframing emphasizes the cardiovascular component of age-related kidney issues.
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