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Updated: Jun 16, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

C-K-D: more vascular damage than kidney disease

M El Nahas, A K Bello

    Prilozi
    |January 21, 2010
    PubMed

    Insights

    Chronic kidney disease (CKD) prevalence is rising globally. This review suggests age-related kidney decline may stem from vascular aging, proposing "Cardio-Kidney-Damage" (C-K-D) as a more accurate definition.

    Area of Science:

    • Nephrology
    • Cardiology
    • Geriatrics
    • Vascular Medicine

    Background:

    • Global increase in Chronic kidney disease (CKD) prevalence.
    • Debate exists whether this reflects true incidence increase or population aging.
    • Age-related kidney function decline is often assumed physiological.

    Purpose of the Study:

    • Reconcile differing views on CKD prevalence increase.
    • Investigate the link between vascular aging and kidney function decline.
    • Propose a new definition for age-related kidney disease.

    Main Methods:

    • Literature review and synthesis of existing research.
    • Analysis of the relationship between vascular aging, atherosclerosis, and kidney health.
    • Conceptual re-framing of age-related kidney disease.

    Main Results:

    • Age-related kidney function decline may not be purely physiological.
    • Diffuse vascular aging and atherosclerosis significantly impact kidney function.
    • These vascular changes affect multiple organs, including the kidneys.

    Conclusions:

    • Age-related kidney disease is potentially a manifestation of systemic vascular aging.
    • The term Cardio-Kidney-Damage (C-K-D) is proposed as a more fitting descriptor.
    • This reframing emphasizes the cardiovascular component of age-related kidney issues.

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