Related Experiment Videos
Clinical experience of targeted therapy
1Division of Clinical Pharmacology, Vienna University School of Medicine, Austria.
Biotherapy (Dordrecht, Netherlands)
|January 1, 1991
Summary
Drug targeting, delivering medication to specific tissues, is a developing field. While promising for various diseases, no system is currently standard for clinical use, though further research is warranted.
Area of Science:
- Experimental pharmacy and pharmacology
- Drug delivery systems
- Clinical pharmacology
Background:
- Drug targeting involves administering drug-carrier conjugates for selective tissue delivery.
- This field has rapidly advanced as a subdiscipline.
- Clinical application of targeted therapy remains limited.
Purpose of the Study:
- To review human studies on targeted therapy.
- To summarize current clinical experience with drug targeting systems.
- To assess the potential of targeted therapy for various indications.
Main Methods:
- Systematic review of human clinical trials.
- Analysis of studies involving drug-carrier conjugates.
- Evaluation of targeted therapy across different disease categories.
Main Results:
- Targeted therapy has been investigated for neoplastic disorders, fungal infections, enzyme replacement, hematologic and immune disorders, and iron storage disease.
- Current clinical experience with targeted therapy is limited.
- No single drug targeting system is recommended for routine clinical practice.
Conclusions:
- Despite limited clinical use, drug targeting shows potential.
- Present findings support continued clinical evaluation of targeted therapy in specific situations.
- Further research is needed to optimize drug targeting systems for widespread clinical adoption.